Scientist, Genome Engineering

Even though biology is unpredictable, you believe we have the tools to engineer it in a predictable way. Your experience and insights help you solve difficult problems and you have mastered new techniques to overcome obstacles. You are passionate about using your skills to make a real-world impact and excited to work with a diverse and multi-disciplined team. Importantly, you have the courage to take on problems others shy away from, and the humility and flexibility to change your approach if biology refuses to comply. And if things don't go as planned, you are kind to others and yourself while troubleshooting and implementing a new course of action.

We are looking for a talented Scientist with knowledge and passion for ambitious synthetic biology projects and large-scale genome engineering for species conservation and de-extinction. We will be building tools and methodologies for engineering various cell types, and will develop workflows to manipulate large DNA fragments and genomes. The candidate will work with a talented group of engineers and biologists committed to developing novel conservation technologies that will change the world.

**This position is based out of Dallas, TX. Relocation assistance is available.**

Duties/Responsibilities:

• Design, innovate and iterate: DNA assembly, integration, editing and screening
• Build enabling molecular and cellular tools
• Perform DNA/RNA transfections and/or viral transductions
• Quantify genome editing events using various molecular assays
• Improve the state of the art in CRISPR-guided precision genome editing
• Data analysis, figure generation and timely reporting of results
• Present findings at small forums and R&D meetings
• Maintain a thorough and detailed electronic lab notebook
• Maintain a clean and organized laboratory space

Basic Qualifications:

• PhD/MS in synthetic biology, bioengineering, molecular biology, genetics or related field is required, or 3+ years hands-on expertise in genetics and genomic manipulation
• Solid understanding and hands-on experience with current precision editing techniques, covering the design, optimization and verification of edits made with CRISPR-Cas9/HDR, Base Editors, nicking-based methods, or large construct integration methods
• Experience with cell culture, DNA/RNA transfection, bacterial culture, recombinant DNA cloning techniques, primer design and PCR, gel electrophoresis, nucleic acid extraction and purification
• Self-motivated, proactive, works well under pressure and deadlines, detail-oriented
• Enthusiasm for learning new skills and taking on new responsibilities
• Strong written and oral communication skills, as well as creative problem-solving skills
• Enjoys the fast-paced startup environment and teamwork

Preferred Qualifications:

• High throughput screening experience or automation methods
• NGS library prep, immunostaining or flow cytometry experience
• Animal tissue culture experience
• Current experience with next-generation, precision editing tools

What Colossal Offers You:

• Medical, dental, and vision coverage
• Unlimited PTO and company holidays so you can rest and recharge
• Flexible spending accounts (FSA)
• Company matched 401k retirement plan
• Paid parental leave up to 12 weeks
• Education reimbursement
• An opportunity to help us return the Earth to a healthier state

The team at Colossal is committed, colorful, passionate, intelligent, collaborative, creative, experienced, scientific and world-class. That sounds like a lot to fit into one building. That’s why we are spread out in three locations that include laboratories, test facilities, academic institutions, libraries and offices. Dallas. Austin. Boston.

Through it all, however, we maintain a culture of positivity, hope, happiness and belief that we’re doing something big. Something Colossal.

Colossal is proud to be an equal employment opportunity workplace. We welcome people from all backgrounds as well as celebrate and support diversity. We are committed to providing an inclusive environment of mutual respect that is free from discrimination and harassment so everyone can thrive.

EEO is the Law

Colossal is proud to be named a Best Place to Work by Built In across 4 categories:

• #1 on the 50 Best Startups to Work For in Dallas!
• 100 Best Places to Work in Dallas
• 50 Best Startups to Work For in Boston
• 100 Best Places to Work in Boston

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